Azilsartan and its Zn(II) complex. Synthesis, anticancer mechanisms of action and binding to bovine serum albumin

Article ID	Journal	Published Year	Pages	File Type
8553975	Toxicology in Vitro	2018	16 Pages	PDF

Abstract

Study of a Zn complex with the designed antihypertensive drug, azilsartan, and their potential anticancer applications.133

Keywords

PBS 4CN Dulbeco's modified Eagle's medium Zincon N-ethyl maleimide Bcl-xL EtBr PMSF PAGE OPT GSSG NAC GSH EGTA Dcf DMEM SDS FBS 2′,7′-dichlorodihydrofluorescein diacetate 2′,7′-dichlorofluorescein 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 4-chloro-1-naphthol ARBs BSA DMSO H2DCFDA MTT N-acetylcysteine o-Phthalaldehyde ROS azilsartan bovine serum albumin Angiotensin II Acridine orange ethidium bromide EDTA ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid Ethylenediaminetetraacetic acid polyacrylamide gel electrophoresis RIPA buffer radioimmunoprecipitation assay buffer Bax Dodecyl sulfate Ang II Dimethyl sulfoxide fetal bovine serum Phosphate buffered saline phenylmethylsulfonyl fluoride B-cell lymphoma-extra large Angiotensin receptor blockers NEM Bcl-2-associated X protein reduced glutathione oxidized glutathione Reactive oxygen species

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Azilsartan and its Zn(II) complex. Synthesis, anticancer mechanisms of action and binding to bovine serum albumin

Authors

Valeria R. MartÃnez, MarÃa V. Aguirre, Juan S. Todaro, Oscar E. Piro, Gustavo A. EcheverrÃa, Evelina G. Ferrer, Patricia A.M. Williams,