Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8554028 | Toxicology in Vitro | 2018 | 55 Pages |
Abstract
Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental contaminants. As such there are a number of well-developed in vitro, in vivo and in silico approaches to evaluate their properties and potential impact on the environment and to humans. Additionally, there is the continual investment in multidisciplinary scientists to explore non-animal surrogate technologies to predict specific toxicological outcomes and to improve our understanding of the biological processes regarding the toxic potential of xenobiotics. Here we provide a concise, critical evaluation of a number of in vitro systems utilised to assess the hepatotoxic potential of xenobiotics.
Keywords
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Pratibha Mistry, Steven D. Webb,