| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8554214 | Toxicology in Vitro | 2016 | 30 Pages |
Abstract
In vitro protocol for screening neuroprotective agents against a dopaminergic toxin. Cellular viability. ROS production and mitochondrial membrane potential were evaluated in slices obtained from rat cortex, hippocampus and striatum incubated with 6-OHDA (100 pM) for l h. Atorvastatin-induced neuroprotection was investigated by co-treating slices with Atorvastatin and 6-OHDA. MK-801, an NMDA receptor antagonist was also tested against in vitro 6-OHDA-induced toxicity. Figure designed using images from www.servier.com/Powerpoint-image-bank.63
Keywords
6-OHDADcfHMG-CoA6-HydroxydopamineDCFHKRbMPTPFCCPdichlorofluorescein1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine2,7-dichlorofluorescein diacetate3-hydroxy-3-methylglutaryl-coenzyme ADMSOH2DCFDAMTTAtorvastatinKrebs–Ringer bicarbonate bufferDimethyl sulfoxideCarbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone
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Authors
Caio M. Massari, Adalberto A. Castro, Tharine Dal-Cim, Débora Lanznaster, Carla I. Tasca,