Cognitive Deficits in Patients With Depression

Cognitive impairment in patients with depression is often overlooked because cognitive deficits and symptoms of depression often overlap. Understanding the neurobiological aspects of cognitive deficits is important, because cognition evolves as a therapeutic target in treating depression. Cognitive symptoms can precede or linger after symptoms of depression, such as sleep, appetite, and affective symptoms, improve. Emerging literature on medications targeting cognition in patients with depression should be considered when clinical decisions are made. Residual cognitive symptoms have been identified as a predictor of poor outcomes when treating depression. Referral to psychiatry should be considered in patients with residual symptoms where diagnosis is unclear.