Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8586257 | The Saudi Dental Journal | 2018 | 5 Pages |
Abstract
Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterized by the triad of microtia, absent or small patellae and short stature. The other associated clinical features may include developmental delay, congenital pulmonary emphysema, gastro-esophageal reflux, urogenital anomalies, such as cryptorchidism and feeding problems. The facial characteristics during childhood are typical, comprising of a small mouth with full lips and micrognathia/retrognathia. The condition is rare affecting about one to nine individuals per million. Mutation in the genes of pre-replication complex involved in DNA-replication is detected in the majority of patients. This impedes the cellular proliferation resulting in a reduction of total cell number and thereby retardation of overall growth. This case report describe the typical dentofacial characteristics in a 5â¯years old child affected with Meier-Gorlin syndrome along with other associated anomalies and a multidisciplinary approach for their management.
Keywords
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Authors
Rahul G. Morankar, Ashima Goyal, Krishan Gauba, Aditi Kapur,