Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8591348 | The Ocular Surface | 2016 | 11 Pages |
Abstract
This study confirms the loss of cytoplasmic/vesicular PPARγ localization in older, atrophic mouse meibomian glands. Furthermore, PPARγ stimulates lipid synthesis in mouse meibocytes, associated with PPARγ sumoylation and translocation to the cytoplasm. Taken together these data suggest that lipid synthesis in older mice is down regulated by a PPARγ mediated pathway.
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Authors
James V. PhD, Eric PhD, Donald J. PhD,