The interaction of polymorphisms in extracellular matrix genes and underlying miRNA motifs that modulate susceptibility to anterior cruciate ligament rupture

In conclusion, this study has implicated inferred allele combinations across BGN (rs1126499, rs1042103), COL5A1 (rs12722) and DCN (rs516115) as well as eight miRNA recognition sequences in susceptibility to ACL rupture. The biological significance of these genomic signatures needs to be explored to understand their effect on the ligaments functional capacity.