Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8611451 | Brazilian Journal of Anesthesiology | 2017 | 9 Pages |
Abstract
Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a surgical procedure overburdens the workload of an anesthetist who is working in a multiâtasking scenario. Going beyond manual administration and Target Controlled Infusion, closedâloop control of Propofol infusion has the potential to offer several benefits in terms of handling perturbations and reducing the effect of interâpatient variability. This paper proposes a closedâloop automated drug administration approach to control Depth Of Hypnosis in anesthesia. In contrast with most of the existing research on anesthesia control which makes use of linear control strategies or their improved variants, the novelty of the present research lies in applying robust control strategy i.e. Sliding Mode Control to accurately control drug infusion. Based on the derived patient's model, the designed controller uses measurements from EEG to regulate DOH on Bispectral Index by controlling infusion rate of Propofol. The performance of the controller is investigated and characterized with real dataset of 8 patients undergoing surgery. Results of this in silico study indicate that for all the patients, with 0% overshoot observed, the steady state error lies in between ±5. Clinically, this implies that in all the cases, without any overdose, the controller maintains the desired DOH level for smooth conduction of surgical procedures.
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Authors
Muhammad Ilyas, Ali Khaqan, Jamshed Iqbal, Raja Ali Riaz,