| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8623343 | Scandinavian Journal of Pain | 2017 | 14 Pages |
Abstract
This article presents synergistic antinociceptive effect produced by the combination of PL265 with non-opioid analgesic drugs acting via unrelated mechanisms. These multi-target-based antinociceptive strategies may bring therapeutic advantages by allowing the reduction of doses, which is of great interest in the chronic treatment of cancer pain.
Keywords
NTIarachidonyl-2′-chloroethylamides.c.FAAHACEAp.o.CCIBNIAEAMORAPNCyPi.p.UHPS.E.M.Per oschronic constrictive injuryAminopeptidase NNaltrindoleFatty acid amide hydrolaseEnkenkephalinsynergistic interactionstandard error of meanintraperitonealDORcancer-induced bone painsubcutaneousNaloxone methiodideNor-binaltorphimineNEPNeprilysinKORHyperalgesiaPeripheralkappa opioid receptorMu opioid receptordelta opioid receptorOpioid receptors
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Authors
Sara González-RodrÃguez, Hervé Poras, Luis Menéndez, Ana Lastra, Tanja Ouimet, Marie-Claude Fournié-Zaluski, Bernard P. Roques, Ana Baamonde,