Peripheral morphine reduces acute pain in inflamed tissue after third molar extraction: A double-blind, randomized, active-controlled clinical trial

- Pain on swallowing after oral surgery with inflamed peridental tissue was reduced by 2 mg local morphine.
- Sedation scores were significantly higher in the peripheral morphine group only 1 h after surgery.
- Patients receiving 2 mg morphine into non-inflamed tissue did not show any reduction in pain scores.