Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8624347 | Journal of Oral Biosciences | 2017 | 8 Pages |
Abstract
These results indicate that sustained Sp7 expression in differentiated odontoblasts inhibits odontoblast maturation and reduces the expression of dentin matrix proteins; however, it fails to induce the transdifferentiation of odontoblasts into osteoblasts, which occurs in Runx2 transgenic mice. Therefore, Sp7 expression needs to be down-regulated to an appropriate level for odontoblast maturation.
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Authors
Toshihiro Miyazaki, Maaya Inoue, Tomomi T. Baba, Toshihisa Komori,