Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8624353 | Journal of Oral Biosciences | 2017 | 8 Pages |
Abstract
Tumor microenvironment comprises tumor cells, various stromal cells, such as carcinoma-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), pericytes, endothelial cells, soluble factors, and extracellular matrix proteins. Tumor-stroma interactions facilitate the progression of head and neck squamous cell carcinoma (HNSCC) in several aspects. HNSCC cells are able to induce normal fibroblasts and macrophages to become CAFs and TAMs, respectively. CAFs can promote HNSCC progression through direct contact and/or paracrine signaling. Such interactions increase the levels of various growth factors, cytokines, chemokines, matrix metalloproteinases, and periostin. TAMs in HNSCC upregulate the production of IL-β, IL-10, and MIP-3α/CCL20, which are involved in tumorigenic processes.313
Keywords
(TGF-β)(VEGF)Tumor-stroma interaction(TNF-α)(IL-6)Interleukin-33interleukin-6interleukin-1betatransforming growth factor-betatumor necrosis factor-alphaHead and neck cancerHepatocyte growth factorstromal cell-derived factor-1Vascular endothelial growth factorCancer-associated fibroblastsTumor-associated macrophagesMatrix metalloproteinasesTumor microenvironment
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Authors
Kusumawadee Utispan, Sittichai Koontongkaew,