Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8624562 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) | 2018 | 36 Pages |
Abstract
In this study, we hypothesized that terrestrial plant oils, rich in alpha linolenic acid (ALA) and stearidonic acid (SDA) relative to fish oil, rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent negative effects on cardiovascular and neurological function using a rat model fed a hypercaloric diet. Results showed effects on the FA profile, namely, eicosapentaenoic, EPA, and docosahexaenoic, DHA, levels. There were also effects on neural aspects (cAMP response element-binding protein, CREB, gene expression, at least, doubled) and the pro-inflammatory/anti-inflammatory balance (TNF-α, tumor necrosis factor alpha reduced by 30-50%). The most positive impact of ALA and SDA was the beneficial reduction of total lipids (from 395â¯Â±â¯3 to 352-361â¯mg/dL), VLDL-cholesterol (from 21.8â¯Â±â¯0.2 to 14.1-17.8â¯mg/dL), and triacylglycerols (from 109â¯Â±â¯1 to 71-89â¯mg/dL) in both LIN (diet enriched in linseed oil) and BUG (diet enriched in Buglossoides oil) groups. Overall, data indicate that ALA- and SDA-rich lipid sources may counteract the undesirable cardiovascular effects of a hypercaloric diet based on milk fat.
Keywords
CREBRPL27mRNA expression levelsVLDLFSTSFAMUFAALTALAGAPDHHDLSDAIL-6GGTEPAlongissimus dorsiBDNFn-3 PUFAForced swimming testASTAspartate aminotransferaseAlanine aminotransferaseALPAlkaline phosphatasealpha-linolenic acidStearidonic acidOleic acidEicosapentaenoic aciddocosahexaenoic acidLinoleic acidsaturated fatty acidn-3 polyunsaturated fatty acidPolyunsaturated fatty acidmonounsaturated fatty acidPUFAinterleukin 6Fatty acid compositiontriacylglycerolTAG یا triacylglycerols tumor necrosis factor alphaBugDHABrain-derived neurotrophic factorTNF-αLinvery low-density lipoproteinhigh-density lipoprotein cholesterolLDLFatty acid methyl esterFAME یا fatty acid methyl esters cAMP response element-binding proteinLow-density lipoprotein cholesterolgamma-glutamyl transpeptidaseglyceraldehyde 3-phosphate dehydrogenase
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Authors
Carlos Cardoso, Joana Paiva Martinho, Paula A. Lopes, Susana Martins, Jorge Correia, Cláudia Afonso, Francisco J. Alarcón, MarÃa J. González-Fernández, Rui M. Pinto, José A. Prates, Narcisa M. Bandarra, José L. Guil-Guerrero,