Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8624584 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) | 2018 | 7 Pages |
Abstract
PGE2 is found to attenuate the bactericidal effects of kanamycin or ampicillin in Staphylococcus aureus, as well as the methicillin-resistant S. aureus (MRSA). Co-treatment with cyclooxygenase (COX) inhibitors (celecoxib, aspirin or naproxen) synergistically enhances kanamycin or ampicillin-induced cell death of S. aureus and MRSA. COX inhibitors repressed bacterial multidrug resistance through down-regulating efflux pump activity in antibiotics-treated S. aureus and MRSA. However, this synergistic bactericidal effects are reduced by the treatment with PGE2. PGE2 restores the efflux pump activity as well as increases biofilm formation in S. aureus and MRSA. Collectively, the enhancement of efflux pump activity and biofilm formation with PGE2 might partially explain the resistance to synergistic bactericidal effects between COX inhibitors and antibiotics in PGE2-treated S. aureus.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Clinical Biochemistry
Authors
Cai Jia-Yi, Hou Yong-Na, Li Jian, Ma Kai, Yao Guo-Dong, Liu Wei-Wei, Hayashi Toshihiko, Kikuji Itoh, Shin-ichi Tashiro, Satoshi Onodera, Ikejima Takashi,