| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8624742 | Bone | 2018 | 11 Pages |
Abstract
By focusing on TGFβ-related genes during OA and chondrocyte hypertrophy in mice, we identified 18 known and 25 new candidate genes potentially implicated in phenotypical changes in chondrocytes leading to OA. We propose that 15 of these candidates warrant further investigation as therapeutic target for OA as they are also regulated in articular cartilage of OA patients.
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Authors
Laurie M.G. de Kroon, Guus G.H. van den Akker, Bent Brachvogel, Roberto Narcisi, Daniele Belluoccio, Florien Jenner, John F. Bateman, Christopher B. Little, Pieter A.J. Brama, Esmeralda N. Blaney Davidson, Peter M. van der Kraan, Gerjo J.V.M. van Osch,