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Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

Article ID Journal Published Year Pages File Type
8624871 Bone 2018 48 Pages PDF
Keywords
BMPRIIBMP type II receptorPROTACSALK2ACVR1fibrodysplasia ossificans progressivaAMPKFKBP12FOPAMP-activated protein kinaseAllostericHeterotopic ossificationPharmacological chaperoneBMPHypoxiaBone morphogenetic proteinProtein kinase
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
Preview
Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification
Authors
Guorong Lu, Mary R. Tandang-Silvas, Alyssa C. Dawson, Trenton J. Dawson, Jay C. Groppe,
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Differential diagnosis: Trepanation
Journal
Bone
Journal: Bone
Related Categories
BMPRII
BMP type II receptor
PROTACS
ALK2
ACVR1
fibrodysplasia ossificans progressiva
AMPK
FKBP12
FOP
AMP-activated protein kinase
Allosteric
Heterotopic ossification
Pharmacological chaperone
BMP
Hypoxia
Bone morphogenetic protein
Protein kinase
Ageing
Biochemistry
Biochemistry, Genetics and Molecular Biology (General)
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Biotechnology
Cancer Research
Cell Biology
Clinical Biochemistry
Developmental Biology
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