Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8624965 | Bone | 2018 | 21 Pages |
Abstract
After a 14-day lag, a single high dose of vitamin D led to greater production of 24,25(OH)2D3, presumably via induction of the 24-hydroxylase enzyme (CYP24A1), relative to the 25(OH)D3 value than did daily vitamin D supplementation, and this effect persisted for at least 28Â days after vitamin D administration. A daily dose of vitamin D may have more lasting effectiveness in increasing 25(OH)D3 with lesser diversion of 25(OH)D3 to 24,25(OH)2D3 than does larger bolus dosing.
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Authors
Hemamalini Ketha, Tom D. Thacher, Sara S. Oberhelman, Philip R. Fischer, Ravinder J. Singh, Rajiv Kumar,