Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8625186 | Bone | 2018 | 11 Pages |
Abstract
After an antibody-free period of four weeks or more, the P1NP response was comparable to the naïve response, and a second phase of treatment with Scl-Ab following an antibody-free period elicited additional gains in BMD. Together, these data demonstrate that the rapid dampening of the bone formation response in the immediate post-dose period which occurs after repeat dosing of Scl-Ab is associated with increased expression of Wnt antagonists, and a treatment-free period can restore the full bone formation response to Scl-Ab.
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Authors
Gill Holdsworth, Kevin Greenslade, Joby Jose, Zofia Stencel, Hishani Kirby, Adrian Moore, Hua Zhu Ke, Martyn K. Robinson,