Contact of myeloma cells induces a characteristic transcriptome signature in skeletal precursor cells -Implications for myeloma bone disease

Article ID	Journal	Published Year	Pages	File Type
8625294	Bone	2016	12 Pages	PDF

Abstract

This study expands knowledge of the myeloma cell contact-induced signature in the stromal compartment of myelomatous bones and thus offers potential targets that may allow detection and treatment of myeloma bone disease at an early stage.

Keywords

LFA-1 Fidgetin ITPR eEF1A1 KISS1R MGUS 5-chloromethylfluorescein diacetate CMFDA ANGPTL4 CA9 MACS PGF PBMCs FCS OPC ABCA1 HBSS PPARγ FACS IL-6 RANKL MSC VEGFA BSA C/EBP Dkk-1 bovine serum albumin ALP Alkaline phosphatase leukocyte function-associated antigen-1 angiopoietin-like 4 interleukin-6 Bone disease Reverse transcriptase fold change annealing temperature fetal calf serum Mesenchymal stem cells peripheral blood mononuclear cells placental growth factor Vascular endothelial growth factor A fluorescence activated cell sorting Hank's buffered salt solution magnetic activated cell sorting gene expression profiling Multiple myeloma Dickkopf-1 CCAAT/enhancer binding protein Carbonic anhydrase IX monoclonal gammopathy of undetermined significance Inositol 1,4,5-trisphosphate receptor receptor activator of NF-κB ligand