Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8626043 | International Journal of Developmental Neuroscience | 2018 | 7 Pages |
Abstract
In the present work we have studied the effect of maternal intake of l-Glutamate (l-Glu) (1â¯g/L) during lactation on group I mGluR transduction pathway in brain plasma membrane from 15 days-old neonates. Results obtained have shown that maternal l-glutamate intake did not significantly affect neither weights of pups nor negative geotaxis reflex, an index of neurobehavioral development, but increased l-Glu plasma level in both male and female neonates. In male neonates, maternal l-Glu intake evoked a loss of mGluR1 whereas no variation on mGluR5 was observed as revealed by Western-blotting assay. The loss of mGlu1R was accompanied by a decrease on l-Glu-stimulated phospholipase C activity suggesting, therefore, a loss of group I mGluR functionality. Concerning female neonates, no variations were detected neither mGluR1 nor mGluR5 and group I mGluR functionality was also preserved.
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Authors
Antonio López-Zapata, David AgustÃn León-Navarro, MarÃa Crespo, Mairena MartÃn,