Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8626339 | Placenta | 2018 | 7 Pages |
Abstract
Oxysterols and LXR inhibit trophoblast survival and differentiation exclusively in conditions of cholesterol scarcity. These findings underscore the importance of cholesterol homeostasis in the maintenance of placental function and suggest that pathways regulating cholesterol homeostasis may represent therapeutic targets to mitigate harmful sequelae of placental injury.
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Authors
C. Miles Harmon, Stacy McGonigal, Jacob C. Larkin,