| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8626363 | Placenta | 2018 | 8 Pages |
Abstract
This study indicates that TGF-β1 upregulates COX-2 expression by activating SMAD2/3-SMAD4 signaling, and elevated COX-2 subsequently contributes to the suppression of human trophoblast cell invasion by TGF-β1. Clinically, targeting TGF-β1/COX-2 could be a useful therapeutic strategy for the treatment of placental disorders.
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Authors
Yuyin Yi, Jung-Chien Cheng, Christian Klausen, Peter C.K. Leung,