Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8627656 | Bone Reports | 2018 | 5 Pages |
Abstract
The main observation of this study is that 5-AZA-induced loss of bone length was registered in 12-mo-old C57 and C3H males. As expected, we did not find differences in the 3rd lumbar vertebra since in-utero exposure to 5-AZA was shown to affect the limb buds but not the axial skeleton. Trajectory of changes in bone phenotypes from ages 3â¯mo through 6â¯mo to 12â¯mo was also compared; 5-AZA-exposed C57 males had consistently lower femoral length and trabecular BMD than age-matched controls. In summary, by characterizing teratogen-exposed C57 and C3H mice, we further confirmed that the adaptive response to antenatal insults continue into mid-life of the mice as well as there is a sex-specificity of these responses.
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Authors
Deepak Kumar Khajuria, Maria Raygorodskaya, Eugene Kobyliansky, Yankel Gabet, Sahar Hiram Bab, Chen Shochat, Arkady Torchinsky, David Karasik,