Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8628841 | Cytokine | 2018 | 6 Pages |
Abstract
We observed significantly low IL6 gene expression in the peripheral mononuclear cells (PBMCs) of schizophrenia patients (tâ¯=â¯3.8, pâ¯=â¯.004) compared to the controls. In addition, schizophrenia patients carrying Del/Del genotype of HLA-G 14â¯bp INDEL exhibited significantly lower IL6 gene expression (tâ¯=â¯3.1; pâ¯=â¯.004) than the Del/Ins as well as Ins/Ins carriers. Our findings suggest that presence of “high-expressor” HLA-G 14â¯bp Del/Del genotype in schizophrenia patients could attenuate IL-6 mediated inflammation in schizophrenia. Based on these findings it can be assumed that HLA-G and cytokine interactions might play an important role in the immunological underpinnings of schizophrenia.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Venkataram Shivakumar, Monojit Debnath, Deepthi Venugopal, Ashwini Rajasekaran, Sunil V. Kalmady, Manjula Subbanna, Janardhanan C. Narayanaswamy, Anekal C. Amaresha, Ganesan Venkatasubramanian,