Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8628864 | Cytokine | 2018 | 8 Pages |
Abstract
Our findings show that IL-27 and IL-37, as well as the pro-inflammatory cytokines, are elevated in HbSS patients compared with controls, suggesting that the secretion of these anti-inflammatory cytokines is driven by the presence of pro-inflammatory cytokines. This role is probably sufficient in preventing further cellular or tissue damage but not potent enough to prevent inflammation. Therefore, IL-27 and IL-37 may be potential immuno-targets for ameliorating complications associated with elevated heme levels seen in SCA and other hemolytic anemias.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
A.E. Alagbe, A.S. Justo Junior, L.P. Ruas, W.V. Tonassé, R.M. Santana, T.H.C. Batista, I.F. Domingos, A.S. Araujo, M.A.C. Bezerra, M.N.N. Santos, M.H.S.L. Blotta,