Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8629356 | Cytokine | 2018 | 6 Pages |
Abstract
The results has shown different composition of analyzed cytokines (IL-1 β, IL-2, IL-4, IL-6, IL-10, IL-17A, TGF-β1, IFN-γ and TNF-α) present in bone marrow and blood of stem cells donors. The hematopoietic stem cells in peripheral blood are subjected to higher levels of proinflammatory cytokines whilst the lower level of those cytokines in bone marrow with a very high level of TGF-β1 which possibly creates a more immunosuppressive environment. The IL-10 level was significantly higher in peripheral blood of PBSC donors after the administration of mobilizing factor (G-CSF). The percentage of CD47+HSCs was significantly higher in bone marrow compared to peripheral blood of mobilized donors.
Keywords
TGF-β1PD-L1GvHDCD47PBSCsT regulatory lymphocytesIFN-γCD274cGVHDTregsAllo-HSCTImmune privilegeinterferon γinterleukinGraft-versus-host diseaseChronic graft-versus-host diseaseTransforming growth factor β1tumor necrosis factor αCytokine levelsStem cellsPeripheral blood stem cellsG-CSFTNF-αProgrammed death ligand 1bone marrowAllogeneic hematopoietic stem cell transplantation
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Authors
Wojciech Fidyk, Iwona Mitrus, Agnieszka Ciomber, Andrzej Smagur, Agata Chwieduk, Magdalena GÅowala-KosiÅska, Sebastian Giebel,