Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8629949 | Diabetes Research and Clinical Practice | 2018 | 34 Pages |
Abstract
This preclinical study shows that promoting Nrf2-mediated antioxidant activity in the localized regenerative milieu of a diabetic wound markedly improves the molecular and cellular composition of diabetic wound beds. RTA 408 treats and corrects the irregularity in redox balance mechanisms involving Nrf2, in an avenue not explored previously for treatment of diabetic wounds and tissue regeneration. Our study supports development of RTA 408 as a therapeutic modality for chronic diabetic wounds.
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Authors
Piul S. Rabbani, Trevor Ellison, Bukhtawar Waqas, Darren Sultan, Salma Abdou, Joshua A David, Joshua M. Cohen, Alejandro Gomez-Viso, Gretl Lam, Camille Kim, Jennifer Thomson, Daniel J. Ceradini,