| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8632822 | Metabolism | 2018 | 39 Pages |
Abstract
Transient exposure to HFD or HG unveiled the presence of an enhancer element at the Ped/Pea-15 gene. Epigenetic changes imposed at this region by diets, which impair glucose tolerance generate metabolic memory of the nutritional injury and leave Ped/Pea-15 induction in a poised state.
Keywords
STDPMTsMNaseH3K4me1H3K27acT2DTSSECLHFDGAPDHGTTinsulin tolerance testEnhancerFAIREchromatin immunoprecipitationITTChromatin remodellingenhanced chemiluminescenceglucose tolerance testmetabolic memoryType 2 diabetestranscription start sitestandard dietHigh fat dietmicrococcal nucleaseCHiPhigh glucoseglyceraldehyde 3-phosphate dehydrogenase
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Authors
Viviana Vastolo, Immacolata Cristina Nettore, Marco Ciccarelli, Luigi Albano, Gregory Alexander Raciti, Michele Longo, Francesco Beguinot, Paola Ungaro,