Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8632829 | Metabolism | 2018 | 33 Pages |
Abstract
Both Helicobacter pylori infection and metabolic syndrome present significant global public health burdens. Metabolic syndrome is closely related to insulin resistance, the major underlying mechanism responsible for metabolic abnormalities, and Helicobacter pylori infection has been proposed to be a contributing factor. There is growing evidence for a potential association between Helicobacter pylori infection and insulin resistance, metabolic syndrome and related morbidity, including abdominal obesity, type 2 diabetes mellitus, dyslipidemia, hypertension, all of which increase mortality related to cardio-cerebrovascular disease, neurodegenerative disorders, nonalcoholic fatty liver disease and malignancies. More specifically, insulin resistance, metabolic syndrome and hyperinsulinemia have been associated with upper and lower gastrointestinal tract oncogenesis. Apart from cardio-cerebrovascular, degenerative diseases and nonalcoholic fatty liver disease, a number of studies claim that Helicobacter pylori infection is implicated in metabolic syndrome-related Barrett's esophagus and esophageal adenocarcinoma development, gastric and duodenal ulcers and gastric oncogenesis as well as lower gastrointestinal tract oncogenesis. This review summarizes evidence on the potential impact of Helicobacter pylori-related metabolic syndrome on gastroesophageal reflux disease-Barrett's esophagus-esophageal adenocarcinoma, gastric atrophy-intestinal metaplasia-dysplasia-gastric cancer and colorectal adenoma-dysplasia-colorectal cancer sequences. Helicobacter pylori eradication might inhibit these oncogenic processes, and thus further studies are warranted.
Keywords
NAFLDLDL-CGITBcl-2HDL-CNADPHNrf2HMG-CoAIGF-1REACLESCRAGERDHbA1cCOXT2DMIGFBPBcl-2-associated protein xTNFNF-κBJanus kinase3-Hydroxy-3-methylglutaryl-CoAERK1/2PPARsROScolorectal adenomaEsophageal adenocarcinomaSTATcyclooxygenaseobstructive sleep apneanonalcoholic steatohepatitisLower esophageal sphincterinsulin-like growth factor receptor-1interleukinBaxOsagastroesophageal reflux diseaseNonalcoholic fatty liver diseasec-JunGastrointestinal tractType 2 diabetes mellitusColorectal cancerGastric cancerMetabolic syndromebody mass indexBMInuclear erythroid 2-related factor 2Helicobacter pylori infectiontumor necrosis factorNuclear factor-kappa BB-cell lymphoma 2Signal transducer and activator of transcriptionMETSBarrett's esophagusInsulin resistanceNash nicotinamide adenine dinucleotide phosphateGlycosylated hemoglobininsulin-like growth factor binding proteinJAKJun proto-oncogeneCRCHigh-density lipoprotein-cholesterolLow-density lipoprotein-cholesterolReactive oxygen speciesPeroxisome proliferator-activated receptors
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Authors
Jannis Kountouras, Stergios A. Polyzos, Michael Doulberis, Christos Zeglinas, Fotini Artemaki, Elizabeth Vardaka, Georgia Deretzi, Evaggelia Giartza-Taxidou, Dimitri Tzivras, Efthymia Vlachaki, Evangelos Kazakos, Panagiotis Katsinelos,