| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8632873 | Metabolism | 2018 | 42 Pages |
Abstract
We demonstrate for the first time that the AFI axis is affected both by acute and chronic energy deficiency. Partial restoration of a component of the axis, i.e. activin B only, through leptin replacement is associated with improved reproductive function in women with HA.
Keywords
HPG-axisGCRCPCOSFstl3AFITGF-βIGF-1Hypothalamic amenorrheastandard deviationEnergyinsulin-like growth factor IAMHTransforming Growth Factor BetaFollistatin-like 3Fastingbody mass indexBMIHypothalamic-pituitary-gonadal axisObesityGeneral Clinical Research Centerfollicle-stimulating hormoneluteinizing hormoneFSH
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Authors
Nikolaos Perakakis, Jagriti Upadhyay, Wael Ghaly, Joyce Chen, Pavlina Chrysafi, Athanasios D. Anastasilakis, Christos S. Mantzoros,