Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8632874 | Metabolism | 2018 | 34 Pages |
Abstract
The results of this study provide new insight regarding the mechanisms by which a pro-hypertensive and pro-inflammatory system, such as RAS, downregulates another anti-hypertensive and anti-inflammatory system such as RDS. Additionally, we propose the use of l-dopa/dopamine index as a biochemical marker of renal dysfunction in conditions characterized by sodium retention, IR and/or hypertension, and as a predictor of response to treatment and follow-up of these processes.
Keywords
RDSFractional sodium excretionGFRAT1RD1RCrClRASNF-kBSBPTGF-β1K+-ATPaseNa+Kidney damageangiotensin II type 1 receptorAngiotensin IIFeNaTransforming growth factor β1tumor necrosis factor αorganic cation transporterUrinary sodium excretionAng IIDopamineRenin angiotensin systemnuclear transcription factor kappa BTNF-αFructosesystolic blood pressurelosartanInsulin resistanceGlomerular filtration rateCreatinine clearance
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Authors
Natalia LucÃa Rukavina Mikusic, Nicolás MartÃn Kouyoumdzian, Ana Uceda, Julieta SofÃa Del Mauro, Marcela Pandolfo, Mariela Mercedes Gironacci, Ana MarÃa Puyó, Jorge Eduardo Toblli, Belisario Enrique Fernández, Marcelo Roberto Choi,