| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8632890 | Metabolism | 2018 | 46 Pages |
Abstract
In a murine model of T2DM, dendritic cells accumulated predominantly in PVAT, as opposed to the vessel wall, per se. Accumulation of dendritic cells in PVAT was associated with overproduction of pro-inflammatory cytokines, which contributed to an impaired ability of PVAT to augment vasorelaxation and exert anti-contractile activity in T2DM.
Keywords
ATAADRFPVATFlt3LT2DMDTRIFN-γIL-6H2SThoracic aortaAChvasodilationAcetylcholineChronic inflammationinterferon-gammainterleukin 6visceral adipose tissueMesenteric adipose tissueperivascular adipose tissuePericardial adipose tissuetumor necrosis factor alphaType 2 diabetesImmune cellsHydrogen sulfideCytokinesTNF-αphenylephrineLADMatVATNitric oxideleft anterior descending coronary arteryDiphtheria Toxin Receptor
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Authors
Tianyi Qiu, Min Li, Miles A. Tanner, Yan Yang, James R. Sowers, Ronald J. Korthuis, Michael A. Hill,