Redox signal-mediated TRPM2 promotes Ang II-induced adipocyte insulin resistance via Ca2+-dependent CaMKII/JNK cascade

Article ID	Journal	Published Year	Pages	File Type
8632921	Metabolism	2018	12 Pages	PDF

Abstract

These data suggested that TRPM2 is a positive regulator of Ang II-induced adipocyte insulin resistance via Ca2+/CaMKII/JNK-dependent signaling pathway. Targeting TRPM2 may be a novel therapeutic strategy to treat hypertension-associated insulin resistance.

Keywords

2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-d-glucose AT1R 2-NBDG OGTT RAS NAC ACA ADPR IRS1 ADP-ribose Jnk CAMK II TRPM2 c-Jun N-terminal kinase Ca2+Ca2+/calmodulin-dependent protein kinase II N-acetylcysteine ROS [Ca2+]i Hydrogen peroxide Adipocyte insulin tolerance test Oral glucose tolerance test enzyme linked immunosorbent assay angiotensin-converting enzyme inhibitors Angiotensin II ITT ELISA Ang II insulin receptor substrate 1 renin-angiotensin system intracellular calcium concentration Insulin resistance ACEI یا angiotensin convert enzyme inhibitor Glucose transporter type 4 H2O2 Glut 4 Reactive oxygen species insulin receptor