FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

Article ID	Journal	Published Year	Pages	File Type
8632999	Metabolism	2018	42 Pages	PDF

Abstract

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in HFD-induced obesity. FNDC5 plays several beneficial roles in obesity and may be used as a therapeutic regimen for preventing inflammation and insulin resistance in obesity and diabetes.

Keywords

SVF PGC-1α p38 IL-1β P65 HFD NOS2 GTT RAW264.7 FNDC5 mTOR CTRL PMS Ym1 Jnk fibronectin type III domain-containing protein 5 LPS AICAR 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside Jun NH2-terminal kinase NF-κB ERK1/2 insulin tolerance test inflammation Interleukin-1β ITT Adipose tissue White adipose tissue compound C glucose tolerance test tumor necrosis factor-α ATMs High fat diet TNF-α nuclear factor-κB lipopolysaccharide Macrophages adipose tissue macrophages Obesity Insulin resistance wild-type nitric oxide synthase 2 mammalian target of rapamycin p38 mitogen-activated protein kinase (MAPK)WAT Stromal vascular fraction Control Peroxisome proliferator-activated receptor gamma coactivator-1α