| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8633012 | Metabolism | 2018 | 36 Pages |
Abstract
These data provide evidence for a contribution of galectin-3 to bone cell maturation and function, bone remodeling, and biomechanical competence, thus identifying galectin-3 as a promising therapeutic target for age-related disorders of bone remodeling.
Keywords
COL1A1carboxy-terminal collagen crosslinksTotal AreaALPLTRAcPSostCt.ThTb.NTb.SpTb.ThOsteoprotogerinVSMCsT-cell factor/lymphoid enhancer factorM-CSFOCNOPGμCTTGFMARqRT-PCRCTXRANKLRUNX2BV/TVTCF/LEFAlkaline phosphataseOsteoblastsOsteocalcinBone strengthOsteoclastsSclerostintartrate-resistant acid phosphataseIHCImmunohistochemistryinterleukinbone remodelingtransforming growth factorMicro-computed tomographytrabecular separationReal time-PCRVascular smooth muscle cellstrabecular numbertrabecular thicknesscortical thicknessRunt-related transcription factor 2Numbermacrophage colony-stimulating factorMacrophagesCortical bone areaMineral apposition ratewild typeCollagen IGalectin-3receptor activator of nuclear factor kappa-B ligand
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Authors
Carla Iacobini, Claudia Blasetti Fantauzzi, Rossella Bedini, Raffaella Pecci, Armando Bartolazzi, Bruno Amadio, Carlo Pesce, Giuseppe Pugliese, Stefano Menini,