Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8633038 | Metabolism | 2018 | 10 Pages |
Abstract
Agmatine results from the decarboxylation of L-arginine in a reaction catalyzed by arginine decarboxylase (ADC), and can be converted to either guanidine butyraldehyde by diamine oxidase (DAO) or putrescine and urea by the enzyme agmatinase (AGM) or the more recently identified AGM-like protein (ALP). In rat brain, agmatine, AGM and ALP are predominantly localised in areas associated with roles in appetitive and craving (drug-reinstatement) behaviors. Thus, inhibitors of AGM or ALP are promising agents for the treatment of addictions. In this review, the properties of DAO, AGM and ALP are discussed with a view to their role in the agmatine metabolism in mammals.
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Authors
José BenÃtez, David GarcÃa, Nicol Romero, Arlette González, José MartÃnez-Oyanedel, Maximiliano Figueroa, Mónica Salas, Vasthi López, MarÃa GarcÃa-Robles, Peter R. Dodd, Gerhard Schenk, Nelson Carvajal, Elena Uribe,