Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway

Article ID	Journal	Published Year	Pages	File Type
8633104	Metabolism	2018	14 Pages	PDF

Abstract

Our results demonstrate a previously unappreciated pathway involving Arg that reverses GH resistance and alleviates malnutrition-induced growth restriction through the inhibition of TLR4-mediated inflammatory pathway.

Keywords

TNFα signal transducers and activators of transcription 5 PTP1B IKKα/β STAT5 Janus Kinase 2 SOCS3 TLR4 TLR JAK2 IGF-1 GHRH GHR LPS mTOR ALA SST Arginine alanine Arg interleukin tumor necrosis factor α Toll-like receptor suppressor of cytokine signaling 3 Malnutrition Somatostatin insulin-like growth factor 1 lipopolysaccharide caloric restriction mammalian target of rapamycin growth hormone-releasing hormone Growth hormone Protein tyrosine phosphatase 1B Liver growth hormone receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

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Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway

Authors

Jingren Xu, Canjun Zhu, Mengyuan Zhang, Qingchun Tong, Xiaojuan Wan, Zhengrui Liao, Xingcai Cai, Yaqiong Xu, Yexian Yuan, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Qianyun Xi, Yong Xu, Qingyan Jiang, Gang Shu,