Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

Article ID	Journal	Published Year	Pages	File Type
8633142	Metabolism	2018	37 Pages	PDF

Abstract

This study indicates that a lipid signature characteristic of T2DM is present years before the diagnosis and improves prediction of progression to T2DM. Molecular lipid biomarkers were shown to have predictive power also in a high-risk group, where standard risk factors are not helpful at distinguishing progressors from non-progressors.

Keywords

hs-CRP IDI NGT FPG OGTT IFG Finnish Diabetes Risk Score LysoPE LysoPC lysophosphatidylethanolamine IGT ROC ALT 2hPG PCE NAFLD FINDRISC 2-hour plasma glucose AUC Oral glucose tolerance test Alanine aminotransferase impaired glucose tolerance Impaired fasting glucose PEE sphingomyelin Integrated discrimination improvement non-alcoholic fatty liver disease normal glucose tolerance triacylglycerol Type 2 diabetes mellitus Cer ceramide Mass-spectrometry phosphatidylethanolamine Fasting plasma glucose Lysophosphatidylcholine Lipidomics area under curve high-sensitivity C-reactive protein ChoE Cholesterol ester glycerophospholipid receiver operating characteristic