| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8633162 | Metabolism | 2018 | 31 Pages |
Abstract
Our data support the concept that EnNaC activation mediates endothelium permeability which, in turn, promotes macrophage infiltration, M1 polarization, and oxidative stress, resulting in cardiac fibrosis and diastolic dysfunction in females with diet induced obesity.
Keywords
DRT3-NTIFRDOCARAASSGK1GAPDHTGF-β13-nitrotyrosineinflammationMRILeft ventricularcardiovascular diseasetransforming growth factor beta 1Magnetic resonance imagingOxidative stressdeoxycorticosterone acetateCVDWestern dietObesityNoxsnicotinamide adenine dinucleotide phosphate oxidaseepithelial sodium channelglyceraldehyde 3-phosphate dehydrogenaseMineralocorticoid receptor
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Authors
Guanghong Jia, Javad Habibi, Annayya R. Aroor, Michael A. Hill, Vincent G. DeMarco, Li E. Lee, Lixin Ma, Brady J. Barron, Adam Whaley-Connell, James R. Sowers,