Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8633167 | Metabolism | 2018 | 33 Pages |
Abstract
The current findings demonstrate that sildenafil can induce browning of sWAT in human, and this action may be through cGMP-dependent protein kinase I and mechanistic/mammalian target of rapamycin (mTOR) signaling pathways. Sldenafil may be a promising treatment for metabolic disease.
Keywords
HDL-CFGF21VASPUCP-1fT3FMDIWATADRB3PGC-1αLC3RMRPDE5IDIO2LDL-CBATcGMPmTORPRDM16FBGIL-6p70 ribosomal S6 Kinase 1Free T3Resting metabolic rateinterleukinsubcutaneous white adipose tissueWhite adipose tissuebrown adipose tissueSWATtumor necrosis factor-alphaFlow-Mediated VasodilationPR domain containing 16fibroblast growth factor 21TNF-αPhosphodiesterase type-5 inhibitorVasodilator-stimulated phosphoproteinfasting blood glucosehigh-density lipoprotein cholesterolcyclic guanosine monophosphateuncoupling protein 1WATtotal cholesterolLow-density lipoprotein cholesterolβ3-Adrenergic receptor
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Authors
Shuguang Li, Yixiang Li, Lin Xiang, Jing Dong, Min Liu, Guangda Xiang,