Apelin, a promising target for Alzheimer disease prevention and treatment

Article ID	Journal	Published Year	Pages	File Type
8633200	Neuropeptides	2018	11 Pages	PDF

Abstract

In this review, we describe the various functions of apelin associated with AD and present an integrated overview of recent findings that, in general, recommend apelin as a promising therapeutic agent in the treatment of this ailment.

Keywords

AMPK PI3K Jnk CAT BACE1 Aβ ACE cGMP ERK PTZ MCP-1 ABCA1 RNS eNOS APP eNO IP3 ICV intracerebroventricular AVP GLP-1 PKC NMDAR inositol triphosphate AT1R NFT TGF QUIN RAGE AAA GSK PLA2 LRP-1 MIP-1α Acetyl choline esterase FDA OXS ICAM-I AMP-activated protein kinase ATP-binding cassette transporter A1 c-Jun N-terminal kinase MPO GSH-Px I/R MAPK Mitogen activated protein kinase kinase PKB/AKT ROS Hydrogen peroxide angiotensin converting enzyme phospholipase A2 Abdominal aortic aneurysm ACh AChE Apoe Acetylcholine Quinolinic acid endothelial nitric oxide ischemia/reperfusion interferon IFN interleukin amyloid beta Alzheimer's disease Alzheimer disease transforming growth factor Oxidative stress tumor necrosis factor alpha Apelin CNS Food and Drug Administration SOD BBB endothelial nitric oxide synthase Superoxide dismutase central nervous system TNF-α phosphatidylinositide 3-kinases Blood-brain barrier MEK Serum deprivation neurofibrillary tangles myeloperoxidase NEP Neprilysin H2O2 arginine vasopressin Presenilin Macrophage inflammatory protein-1α monocyte chemoattractant protein-1 amyloid precursor protein protein kinase B Protein kinase C mitogen-activated protein kinase Pentylenetetrazole glucagon-like peptide-1 Catalase extracellular signal-regulated kinase glutathione peroxidase glycogen synthase kinase Guanosine monophosphate reactive nitrogen species Reactive oxygen species N-methyl d-aspartate receptor Receptor for advanced glycation end products