Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8633521 | Neuropeptides | 2017 | 8 Pages |
Abstract
CGRP release evoked by depolarisation of meningeal afferents is accompanied by increased blood flow in the medulla oblongata but not the dura mater. This discrepancy can be explained by the smooth muscle depolarising effect of KCl and the activation of sympathetic vasoconstrictor mechanisms. The medullary blood flow response is most likely mediated by CGRP released from activated central terminals of trigeminal afferents. Increased blood supply of the medulla oblongata and CGRP release into the CSF may also occur in headaches accompanying vigorous activation of meningeal afferents.
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Authors
Mária Dux, Christine Will, Mirjam Eberhardt, Michael J.M. Fischer, Karl Messlinger,