Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8644394 | Gene | 2018 | 28 Pages |
Abstract
Thoracic aortic aneurysm is extremely threatening due to high risk of dissection and rupture. Genetic factors play decisive role in the pathogenesis of thoracic aortic aneurysm. Recent years, several genes are considered to be associated with thoracic aortic aneurysm, among these genes, 11 gene variants identified are responsible for thoracic aortic aneurysm. In this review, we mainly discussed the function of the 11 gene variants in thoracic aortic aneurysm and the histology and cytokine signaling alterations induced by these gene variants.
Keywords
transforming growth factor beta receptor 2FBN1TAADR-SmadsTGFBR1LDSTGFB2Loeys–Dietz syndromeTGFBR2Angiotensin II type I receptorMAT2AAAAMFSAT1RMYLKCTGFTAAACTA2PDASMCMYH11TGF-betaAortic aneurysmThoracic aortic aneurysmsThoracic aortic aneurysmAbdominal aortic aneurysmTransforming Growth Factor Betatransforming growth factor beta 2transforming growth factor beta receptor 1myosin light chain kinaseSmooth muscle cellMarfan Syndromereceptor-regulated SmadsConnective tissue growth factorFibrillin 1Patent ductus arteriosusGeneVariants
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Authors
Lifei Wu,