Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8644467 | Gene | 2018 | 42 Pages |
Abstract
With the advent of recent advances in molecular techniques and whole genome sequencing, we have come to know that the non-coding landscape (including non-coding RNAs, tRNAs and even telomeres) plays a major role in the regulation of cellular processes. Furthermore, the deregulation of this landscape has been found to contribute to and even bring about the pathogenesis of a large number of diseases. One of such diseases is diabetes mellitus (type 2 specifically) whose incidence rate and global burden is constantly increasing. Nutrition has been proven to be a key player in the development, onset and control of type 2 diabetes mellitus. Additionally, non-coding DNA based molecular markers are emerging as biomarkers of T2D, susceptibility, and perhaps dietary supplements can modulate non-coding DNA based markers expression and function in T2D management. In this review, we provide a brief overview of the developmental origins and genetics of type 2 diabetes mellitus, how each component of the non-coding landscape contributes to the development and progression of the disease and finally we discuss how dietary interventions modulate the non-coding landscape in T2D.
Keywords
Cdkal1TIN2POT1Repressor activator protein 1HNF4ANeuroD1KCNJ11IRS1ABCC8Calpain 10HMGA1RAP1INSRTRF2telomeric repeat binding factor 2TRF1telomeric repeat binding factor 1High Mobility Group A1CAPN10HNF1βGLIS3hepatocyte nuclear factor 1APPARγLBWLPLTPP1HNF1AlncRNAIFGT2Dlong non-coding RNAUCPsImpaired fasting glucoseNutritionUncoupling proteinsprotection of telomeres 1Diabetes mellitusMaturity-onset diabetes of the youngType 2 diabetesType 2 diabetes mellitusinsulin receptor substrate 1Lipoprotein lipaseMODYMicro-RNAMiRNALow birth weightpiwi-interacting RNAinsulin receptorPeroxisome proliferator-activated receptor-γ
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Marwa Matboli, Ayman Shafei, Mahmoud Ali, Kamal M. Kamal, Mahmoud Noah, Paula Lewis, Abdulrahman Habashy, Mohamed Ehab, Ahmed I. Gaber, Hana Abdelzaher,