Clinical variables and ethnicity may influenced by polymorphism of CAT â262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications

Article ID	Journal	Published Year	Pages	File Type
8644730	Gene	2018	45 Pages	PDF

Abstract

Our results revealed that polymorphisms of CAT and MnSOD may be associated with physiopathology causing the onset of T1D. Our data, suggest that the genotypic frequencies of these SNPs appear to be influenced by clinical variables and by the Arab-Berber ethnic origin of the Algerian population.

Keywords

HbA1c NF-kB HWE NFI RNS AP-1 CAT MnSOD PKC ERN ERO Jnk T1D MDR1 NOD2 PTPN22 CARD15 Nucleotide-binding oligomerization domain 2 MDA InsP Janus kinase DNA ROS Sp-1 STAT Human leukocyte antigen HLA deoxyribose nucleic acid Hardy–Weinberg equilibrium Oxidative stress Type 1 diabetes World Health Organization SOD Age manganese superoxide dismutase Superoxide dismutase body mass index BMI Nuclear factor I Transcription factors nuclear factor kappa-B diastolic blood pressure systolic blood pressure Signal transducer and activator of transcription PAS Glycated hemoglobin PAD activator protein-1 multidrug resistance protein 1 Protein kinase C Polymorphism Single nucleotide polymorphisms SNP JAK Catalase WHO reactive nitrogen species Reactive oxygen species