Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8645054 | Gene | 2018 | 25 Pages |
Abstract
Two new neuroblastoma susceptibility loci at 3q25 (RSRC1 rs6441201 Gâ¯>â¯A) and 4p16 (CPZ rs3796725 Tâ¯>â¯C and rs3796727 Aâ¯>â¯G) were identified by a genome-wide association study (GWAS) involving Italians, African Americans and European Americans. In this case-control study with 393 neuroblastoma cases and 812 controls, we investigated the association between these three polymorphisms and neuroblastoma susceptibility in Chinese population. We found that participants harboring the RSRC1 rs6441201A allele were associated with an increased risk of neuroblastoma (AA vs. GG: adjusted ORâ¯=â¯1.55, 95% CIâ¯=â¯1.03-2.34, Pâ¯=â¯0.036). No significant association between the CPZ polymorphisms (rs3796725 Tâ¯>â¯C and rs3796727Aâ¯>â¯G) and neuroblastoma susceptibility was observed. In conclusion, our results confirm that the RSRC1 rs6441201A allele is associated with neuroblastoma susceptibility in Chinese population.
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Authors
Jue Tang, Wei Liu, Jinhong Zhu, Jiao Zhang, Feng-Hua Wang, Jiang-Hua Liang, Jia-Hang Zeng, Hui Wang, Huimin Xia, Jing He,