Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8645063 | Gene | 2018 | 24 Pages |
Abstract
Accumulating evidence suggests that the aberrant expression of long non-coding RNAs is closely related to the carcinogenesis and progression of gastric cancer (GC), which is a type of prevalent tumor with a high incidence and mortality rate. However, it is still a challenge to find reliable biomarkers and to understand their molecular mechanisms in GC. In this study, we first confirmed that LINC00941was up-regulated in GC tumor tissues compared with adjacent normal tissues by RT-PCR, and found that the expression level of LINC00941 was correlated with invasion depth, lymphatic metastasis, and the TNM stage of patients with GC. Furthermore, by performing enrichment analysis based on the co-expression network and regulatory network, we found that LINC00941 was associated with cancer related biological processes such as cell cycle, cell communication, cell migration, cell division, as well as processes associated with the immune system. Our results suggested that LINC00941 may be a potential novel biomarker for therapeutic or diagnostic of GC.
Keywords
EGFRCCAT1CBX7INK4ARBPJFOXK1HULCPCGsHOX transcript antisense RNAH19G3BP1lncRNAsRT-PCRFOXP3miRNAsRBPslong non-coding RNALong non-coding RNAsforkhead box P3KEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and GenomesWorld Health Organizationlung adenocarcinomaGastric cancerregulatory networkTranscription factorLUADMicroRNAHOTAIRreal-time polymerase chain reactionRNA-binding proteinsprotein coding genesJunWHOEpidermal growth factor receptor
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Authors
Cong Luo, Yang Tao, Yuwei Zhang, Yinyin Zhu, Derry Ng Minyao, Maria Haleem, Changzheng Dong, Lina Zhang, Xiaohong Zhang, Jinshun Zhao, Qi Liao,