Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction

Article ID	Journal	Published Year	Pages	File Type
8645104	Gene	2018	37 Pages	PDF

Abstract

In conclusion, POLR1B, POLE3, POLD3, and HTR2C might play important roles in obese PCOS via involvement of pyrimidine metabolism and calcium signaling pathway. Moreover, AR, ADRB2, and OAZ3 might be targets of spironolactone, trimipramine, and L-ornithine in the treatment of obese PCOS.

Keywords

CTD Arg2 ADRB2 SRD5A1 PCOS RMA Comparative Toxicogenomics Database TFs DEGs Chrm3 STRING nES miRNAs NR3C2 PPI HTR2C GEO arginase 2 search tool for the retrieval of interacting genes/proteins Molecular function Microarray analysis Protein-protein interaction cellular component KEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and Genomes FTO DAVID microRNAs Polycystic ovary syndrome ORA Transcription factors biological process Robust multi-array average normalized enrichment score Gene ontology database for annotation, visualization and integrated discovery Gene Expression Omnibus Differentially expressed genes Androgen Receptor