Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8645320 | Gene | 2018 | 28 Pages |
Abstract
The miRNAs differentially expressed in neutrophils are predominantly implicated in signalling pathways leading to cytokine productions. Here, the decreased expression in TB cases may imply a lack of suppression on signalling pathways, which may lead to increased production of pro-inflammatory cytokines such as interferon-gamma. Furthermore, the miRNAs differentially expressed in B-cells are mostly involved in the induction/suppression of apoptosis. Further functional studies are however required to elucidate the significance and functional effects of changes in the expression of these microRNAs.
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Genetics
Authors
I.C. van Rensburg, L. du Toit, G. Walzl, N. du Plessis, A.G. Loxton,