| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8645472 | Gene | 2018 | 33 Pages |
Abstract
Considering the contradictory role of PPARγ on tumorigenicity, a number of studies demonstrate mechanisms involved in tumorigenicity effects of PPARγ agonists while several studies suggest key roles of PPARγ agonists in anti-proliferation, metastasis, angiogenesis, apoptosis and immunomodulatory through activation of signaling pathways in different cancer cells as well as in cancer stem cells. The aim of this review is summarizing of tumorigenicity and anti-tumorigenicity activities of PPARγ agonists and antagonists as well as therapeutic activities of these reagents as a coadjutant drug in the treatment of different cancers.
Keywords
EPAACCIL-6DOXRPTCATCSCsmTORCOX-2MMP-9MMP-2CMLRac1HIF-1αHDACiEAAT2S1PHMGB1GSK3βPARPTLR4HDAC1RAGEMUC16TumorigenicityMDSCsp38MAPKAKR1B10VPACDK4ACLYATP citrate lyaseTZDSCD1PPERetinoid X receptorsPPARγ agonistRGZRXRsPGCsSMRTLSCsPCNApGzTGZLIFCDKIscaspase activated DNase15-d-PGJ2CBP/p300HCCNFκBPI3K/AKTPPARsROSProliferating Cell Nuclear AntigenPPREStearoyl-CoA desaturase 1acetyl-CoA carboxylasesphingosine 1-phosphateEicosapentaenoic aciddocosahexaenoic acidfatty acid synthaseinterleukin 6BADGETERTTroglitazoneTelomerase reverse transcriptasetumor necrosis factor-αEMTThiazolidinedioneDoxorubicinDHAretinoblastomarosiglitazonesteroid receptor coactivatorsSODLeukemia stem cellsCancer cellsCancer stem cellsSuperoxide dismutaseCyclooxygenase-2CADleukemia inhibitory factorPomegranate peel extractTherapeutic agentsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nuclear factor κBFasnphosphatase and tensin homologchronic myelogenous leukemiaRenal proximal tubulematrix metallopeptidase 9histone deacetylase inhibitormammalian target of rapamycinhistone deacetylase 1Valproic acidCREB-binding proteinp38 mitogen-activated protein kinasepoly ADP ribose polymerasePtenCatalaseHepatocellular carcinomaEpithelial-mesenchymal transitionPioglitazoneglycogen synthase kinase 3 betaReactive oxygen speciesReceptor for advanced glycation end productsToll-like receptor 4Peroxisome proliferator-activated receptors
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Authors
Saghar Yousefnia, Sara Momenzadeh, Farzad Seyed Forootan, Kamran Ghaedi, Mohammad Hossein Nasr Esfahani,